I have 3 games that do pretty much this when I try to boot the exploit and I have to re format my card and install UNO again (took a bunch of trial and error to find the games that were crashing it from working.) but now I have them all working fine, as soon as I try to copy one of the 3 though, kills it and I have to format it and start over..
I can also say I noticed holding the start down doesn't work on many of my games now, I have to reboot the vita once it locks up as if I kill the psp mode (hitting ps button) then re-open UNO, it locks up completely and I have to hole power down until a hard reset is done to get out of it.
Total_Noob's PSP Emulator Custom Firmware for the Vita. CEF can be downloaded here.